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Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea โ the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea โ reported at moderate frequency Constipation โ less common than nausea but clinically relevant for some participants Vomiting โ generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies
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