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Robust evidence from landmark CVOTs, such as LEADER, SUSTAIN-6, and SELECT has proven GLP-1 agonists serve as essential treatment options for T2DM patients at high cardiovascular risk and indicate their growing applications in HFpEF and non-diabetic patients and cerebrovascular disease
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4 Similarly, in tirzepatide’s SURMOUNT-1 study, 9-15% lost less than 5% and 16-31% loss less than 10% (dose-dependent)
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