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GLP-1 receptor agonists: Semaglutide 2.4 mg produces 12% to 15% total body weight loss over 68 weeks in the STEP trials (Wilding et al., New England Journal of Medicine , 2021)
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The Centers for Medicare & Medicaid Services (CMS) issued proposed guidance in February 2026 clarifying that "obesity treatment" under the ACA's preventive services mandate includes pharmacotherapy when prescribed by a licensed provider
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