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In particular, long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can cause gastric mucosal damage as they can inhibit mitochondrially encoded cytochrome C oxidase I (MT-CO1, also known as COX-1) and block its protective effect on gastric mucosa

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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ