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While clinical trials of tirzepatide included patients with various medical histories, specific subgroup analyses focused on post-cholecystectomy patients have not been published
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Ligand-independent actions of estrogen receptors (ERs) have also been described, particularly in the uterus, where ERα can be activated by growth factor pathways (e.g., IGF-1), leading to receptor recruitment to chromatin in the absence of estrogen binding (Meyer et al., 2011
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