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IL-6 is critically needed under physiological conditions to maintain intestinal epithelial barrier, intestinal epithelial cell proliferation, intestinal stem cell niche and mucin production to maintain the gut homoeostasis, including its healing post-intestinal injury/inflammation [79–83]

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Tirzepatide reduced symptoms of OPS by nearly two-thirds, or 66% in some adults, while a placebo only resulted in a reduction of 5%