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Additionally, the following conditions may warrant careful consideration based on clinical judgment, though evidence specifically linking these conditions to increased risk with tirzepatide is limited: History of significant gastrointestinal motility disorders that could be exacerbated by further slowing of gastric emptying Inflammatory bowel disease with active inflammation or history of stricturing complications Recent abdominal surgery , particularly procedures involving the gastrointestinal tract Severe chronic constipation that is difficult to manage Regarding pancreatitis, the FDA label advises clinicians to consider alternative antidiabetic therapy in patients with a history of pancreatitis, as GLP-1 receptor agonists have been associated with acute pancreatitis in some cases

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This hormone is released from the gut after eating and plays a significant role in regulating blood sugar and appetite