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Dose-related effects on the rat fetus (structural abnormalities and reduced body weight) occurred only at higher dosages, equal to or greater than 150 mg/kg (more than 2344-times the 10 mg clinical dose, based on AUC), which were associated with maternal toxicity
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As of August 2026, the FDA has not required Novo Nordisk to add a NAION warning to Wegovy’s label
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