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More recently, long-acting GLP-1 RAs for obesity have been approved: semaglutide (approved in 2021), resulted in an average weight reduction of around 15% 12–14 , and tirzepatide (approved in 2023), demonstrating an average weight reduction of approximately 20% 15–17
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GLP-1 agonists offer evidence for longer-term use and address metabolic dysfunction directly
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