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For instance, in a study, the concomitant administration of 10 mg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (twice daily) on the first 2 days of treatment with metformin (150 mg/kg four times daily) for 7 consecutive days significantly inhibited microglia activation and worsened dopaminergic neuron damage (Katila et al., 2017)
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