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Moreover, GLP-1R–deficient β cells exhibit enhanced sensitivity to apoptotic injury, whereas pharmacological activation of GLP-1R signaling attenuated β cell death in mice in vivo, as well as in cultures of purified rat β cells studied ex vivo (70)
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Recent clinical trials show that GLP-1/GIP dual agonists can significantly improve body weight, fasting and after-meal blood glucose levels, insulin sensitivity, and total cholesterol
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