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In a post hoc analysis of SURPASS-4, tirzepatide treatment was associated with a significant reduction in composite renal outcome events (time to first occurrence of at least 40% decline in estimated glomerular filtration rate from baseline, end-stage renal disease, renal-related death, or incident macroalbuminuria) compared with treatment with insulin glargine (HR = 0.58
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Pregnant or breastfeeding women also should not use them
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