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Authors: Karen G Farrar ⊕ University of Southern California , Los Angeles, CA, Duy Do ⊕ Truveta, Inc , Bellevue, WA, Nina B Masters ⊕ Truveta, Inc , Bellevue, WA, Brianna M Cartwright ⊕ Truveta, Inc , Bellevue, WA After CVS Caremark made anti-obesity semaglutide the preferred formulary option in July 2025, switching from anti-obesity tirzepatide surged from 0.6% to 9.7%, representing more than a 16-fold rise
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A 2019 meta-analysis of 74 trials (N = 358,000) found that systolic BP below 90 mmHg was associated with increased mortality in patients over 60, reversing the protective effect seen at higher BP (Bavishi et al., JAMA Cardiology 2019)
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