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For example, nucleotide-binding oligomerization domain 2 (NOD2, a cytosolic sensor of muramyl dipeptide (MDP), a component of the peptidoglycan (PGN) present in the bacterial cell wall), TLR4 and CD14 KO mice produce lower GLP-1 levels (figure 2) and exhibit altered gastric emptying in response to HFD, indicating gut microbiota and their recognition by intestinal PRRs critical to induce the IL-6 release are critical factors for GLP-1 production [100,102–104]
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The gap reflects differences in trial duration, population, and what counted as a reason to stop
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