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The Role of Genetic Testing in Tailoring GLP-1 Response Emerging research suggests that variants in GLP-1 receptor (GLP1R), glucose-dependent insulinotropic peptide receptor (GIPR), melanocortin-4 receptor (MC4R), and fat mass and obesity-associated protein (FTO) genes influence individual metabolic responses and appetite-suppression sensitivity

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Over-the-counter antimotility agents like loperamide can provide short-term relief, but avoid regular use without medical approval—slowing intestinal transit while your body is adapting to semaglutide may trap gas and cause bloating