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In murine models of obesity and diabetes, administration of the chemical chaperones phenyl butyric acid (PBA) and tauro-ursodeoxycholic acid (TUDCA), increased systemic insulin sensitivity, established normoglycemia, reduced fatty liver disease, and suppressed inflammatory signaling (137)

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Adipose tissue (body fat) is not merely an energy store but an active endocrine organ that produces and metabolises hormones, particularly oestrogen