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Lastly, PKC is involved in microvascular dysfunction, causing impaired blood flow to peripheral nerves, since hyperglycemia activates PKC [61], and activated PKC limits intracellular calcium levels involved in calcium signalling pathways of α 1 ‐adrenoceptor in resistance arteries [62]

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Clinical Evidence We currently have very limited evidence in support of the use of GLP-1 or dual GIP/GLP-1 medications in treating adults with type 1 diabetes