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Rather, its effects on weight and energy use are mediated through appetite suppression, improved glucose handling, and subsequent changes in body composition
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In addition, both in vitro and in vivo Interleukin-6 (IL-6) has shown to be a powerful GLP-1 secretagogue, capable to positively modulate both the proglucagon gene, and the expression of PC1/3 in α-cells and intestinal L-cells (225, 226)
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