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Compounds marketed as dual or triple agonists, such as tirzepatide, act at combinations of the GLP-1, GIP, and glucagon receptors rather than at any third GLP receptor
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Human islet histology Human islets were incubated overnight in medium plus 11 mM glucose ± 100 nM agonist prior to transfer to 4 °C to arrest endocytosis and labeling with 1 μM exendin-FITC, PFA fixation, 70% ethanol dehydration and suspension in 4% agarose small plugs
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