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Another randomized controlled clinical trial specifically focusing on their weight loss effects demonstrated that, in adults with overweight or obesity without diabetes, once-weekly subcutaneous injection of semaglutide resulted in significantly greater weight loss at 68 weeks compared with once-daily subcutaneous injection of liraglutide, and the incidence of gastrointestinal adverse reactions was similar between the two groups [Reference Rubino, Greenway, Khalid, O’Neil, Rosenstock and Sørrig47]
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