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Keywords: GLP-1 receptor agonists, hepatocellular carcinoma (HCC), liver fibrosis, epigenetic reprogramming, DNA methylation, histone modifications, hepatic stellate cells (HSCs), metabolic dysfunction-associated steatotic liver disease (MASLD), cellular senescence, Sirtuin 1 (SIRT1) Abstract The liver’s susceptibility to age-related diseases, including hepatocellular carcinoma (HCC), is increasingly linked to progressive epigenetic alterations that disrupt gene regulation, promote fibrosis, and impair regeneration
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