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Science 2005;308:1043–1045 [DOI] [PMC free article] [PubMed] [Google Scholar] 126
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Thus, combining GIPR and GLP-1R agonism may enhance insulin secretion in patients with T2D by first rescuing dysfunctional beta-cells with GLP-1R agonism followed by additive effects on insulin secretion provided by both receptors
