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GLP-1RAs have been shown to shift microglia away from pro-inflammatory M1/DAM states toward anti-inflammatory or homeostatic phenotypes (sometimes likened to M2/A2) [147]
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Remember that semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and is not recommended for weight management during pregnancy
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