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Both central and peripheral administration of GLP-1R agonists increase HR and BP in rodents [[636], [637], [638]], with induction of c-Fos expression in adrenal medullary catecholamine neurons and activation of tyrosine hydroxylase, the key enzyme involved in production of norepinephrine, in the brainstem [638]

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Measurable weight loss is typically visible by weeks 4-8