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Small-Molecule Drugs To summarize the current approaches for obesity treatment based on GLP-1 analogs, when it comes to the drug design, there are two main strategies: (1) Multiple receptors targeting: This strategy involves the peptide drugs which are binding two or more (usually incretin) GPCRs

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The magnitude of difference was particularly notable for weight loss, suggesting that GIP receptor activation contributes meaningfully to metabolic improvements beyond GLP-1 effects alone