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The study concluded that in poorly controlled T2DM patients on metformin monotherapy, addition of glimepiride was associated with faster glycemic control, lower total cholesterol, and low-density lipoprotein (LDL) as well as reduced short-term health care costs compared to the addition of pioglitazone, which was associated with a higher rate of peripheral edema (4% vs 1% with glimepiride)

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