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retatrutide achieved 24.2% at 48 weeks in Phase 2 (12mg) and 28.7% at 68 weeks in Phase 3 (12mg, OA population)
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This is a potentially huge shift in future treatment strategies for HFpEF, as current guideline-directed therapies only include sodium-glucose cotransporter 2 inhibitors, aldosterone antagonists, and angiotensin receptor–neprilysin inhibitors
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