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The bio-availability of the DPP-4 inhibitors is very good and the pharmacodynamic- as well as the pharmacokinetic characteristics lead to the above mentioned clinically sufficient DPP-4 inhibition with once daily dosing (only vildagliptin has to be dosed twice daily) (18, 19)

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Used pens and needles should be placed in an FDA-cleared sharps container or a heavy-duty plastic container with a secure lid (such as a laundry detergent bottle)