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Therefore, due to the potential severity of pancreatitis, clinicians should alert patients to pay attention to the symptoms after administration of semaglutide to mitigate the risk

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According to FDA-approved labeling and clinical trial data, the following side effects occur most commonly: Gastrointestinal Effects: Nausea (affecting 15–44% of patients, with higher rates at Wegovy doses) [3] [4] Diarrhea (reported in 8–30% of patients) Vomiting (5–24% incidence) Constipation (occurring in 3–24% of patients) Abdominal pain (5–20% of patients) These gastrointestinal symptoms typically emerge during dose escalation and often diminish with continued therapy as physiological adaptation occurs