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"Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials"

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This recommendation is based on compelling evidence: an early-responder analysis showed that 93.4% of patients who failed to meet the 16-week threshold were also unable to achieve a substantial (≥10%) weight reduction after a full year of treatment