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Insulin glargine was given to female rats before mating, during mating, and throughout pregnancy at doses up to 0.36 mg/kg/day, which is approximately 50 times the recommended human subcutaneous starting dosage of 0.2 Units/kg/day (0.007 mg/kg/day)
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Several other commonly used drugs like lisinopril, warfarin, metformin, digoxin, ethinyloestradiol/levonorgestrel, rosuvastatin and furosemide have been evaluated but no clinically relevant change in the exposure of semaglutide has been seen in drug–drug interaction studies [Figure 5]
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