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In receptor-binding studies, tirzepatide demonstrated a high affinity for the GIPR, comparable to that of native GIP, while its affinity for the GLP-1R is approximately 18- to 20-fold weaker than that of native GLP-1 [33]

CAS 2023788-19-2

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10.1016/j.bbrc.2018.03.142 12 ChenX.ZhaoP.WangW.GuoL.PanQ