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Pancreatic α-cells have been demonstrated to express and secrete not only GLP-1 (205, 206), but also PYY (35) GIP (207, 208) mini-glucagon (209) or even Xenin (210) together with glucagon (Figure 2)
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It points to appetite suppression, blood sugar response and side effects during the titration phase as the signals that indicate whether the current amount is working
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