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Those taking GLP-1 (glucagon-like peptide-1) medications for diabetes and weight loss often experience gastrointestinal symptoms – but some lesser-known side effects have also been reported
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(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic β-cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)
