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These cytokines are mechanistically relevant, as activating the TNF-α signaling pathway leads to hypertension, atherogenesis, vascular dysfunction, and unfavorable cardiac remodeling following MI [48], while IFN-γ contributes to the progression of atherosclerotic CVDs through the JAK/STAT pathway [49]
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Dose-related decreases in food consumption, bodyweight gain, and crown-rump length were seen
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