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Week 5-8 (dose escalation through 7.5 mg): Each dose increase can temporarily reintroduce sleep disruption for 7-10 days as the body adjusts to stronger effects
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Viral-vector delivery of KORD or hM3Dq receptor-based DREADDs to the OB was performed in Glp1r -Cre mice on RD ( Glp1r RD mice) and WD ( Glp1r OB-hM3Dq WD mice) diets, respectively (Fig
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