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In this case, semaglutide was administered subcutaneously once weekly, starting at 0.25 mg for 4 weeks, increasing to 0.5 mg for another 4 weeks, and then maintained at 1.0 mg weekly, with dose adjustments allowed based on tolerability and participant-specific needs

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GLP-1 effects on energy expenditure A role of endogenous GLP-1R signaling in the control of energy expenditure was inferred from studying mice with congenital GLP-1R deficiency