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Further, the CVOTs in general also suggested a potential benefit of GLP-1 RAs on HF, positioning GLP-1 RAs as another advanced option alongside SGLT2 inhibitors in the otherwise sparse treatment armamentarium for especially HFpEF
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A meta-analysis of 22 experiments found that GLP-1 agonists resulted in a significant increase in heart rate compared with placebo, with a weighted mean difference of 1.86 beats per minute (bpm) and 1.90 bpm compared with active control
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