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Sources New England Journal of Medicine, STEP 1 trial of semaglutide 2.4 mg (2021): New England Journal of Medicine, SURMOUNT-1 trial of tirzepatide (2022): New England Journal of Medicine, SURMOUNT-5 head-to-head trial (2025): Saxenda (liraglutide) prescribing information and SCALE trial data: See your options in about 2 minutes Take the free quiz and see what fits you