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The model of BMI-loss efficacy demonstrated good performance in the self-report data, explaining 25% of the variance ( R 2 ) in both the training set and held out test set, with most of the variance explained by non-genetic factors (Supplementary Table 20)
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Peripheral administration of recombinant FGF1 in hyperglycemic mice produces robust glucose control and enhanced insulin sensitivity, actions dissociated from changes in cell proliferation, weight gain, or bone loss [27]
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