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This may be a feedback protection mechanism when the body suffers severe damage ( FIGURE 1 The effect of GLP-1Ras on sepsis: 1) The effect of blood glucose homeostasis: The endogenous GLP-1 and exogenous GLP-1Ras secreted in the small intestine bind to GLP-1R on the surface of the pancreas, stimulate Ca2+ influx and reduce K+ outflow through cAMP activation of PKA/EPAC signaling pathway, promote insulin secretion, and regulate blood glucose homeostasis 2) Inflammation response: GLP-1R is expressed in macrophages and monocytes, and can inhibit the release of inflammatory factors through TNF-α, AMP/PKA and other pathways to reduce systemic inflammatory response