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The Premise of the Paradox: Examining the Evidence That Motivated GIPR Agonist and Antagonist Drug Development Programs

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The emergence of tri-agonists, combining GLP-1R/GIPR and glucagon (GCG) receptor (GCGR) agonists (GLP-1R/GIPR/GCGR agonist), has also shown promising results by leading to more significant weight loss, a greater percentage of individuals attaining weight loss, further lowering lipid levels, improving T2DM management, and enhancing overall substrate metabolism compared to the use of GLP-1R agonists alone (Lyons & Beaudry 2023)