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Weight loss has taken over the GLP-1 conversation—but cardiologists are paying attention to something else entirely: the heart-protective benefits that show up even without major weight changes. Visceral fat, insulin resistance, and

Wang L, Zhan X, Wang Z, Ma J, Chang X, Zhu X

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Layering on requirements for optimal pharmacological profiles and drug-like properties to support oral dosing adds another level of complexity.’ But acording to Terry Kenakin, a former GSK drug developer now at the University of North Carolina-Chapel Hill in the US, ‘we are in what I call a renaissance in terms of finding compounds that modify the function of these [GPCR receptors]’