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This can result from: For some, this fatigue feels similar to early diabetic fatigue, which emphasizes the need to monitor metabolic markers closely

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The pre-PVSG era included mostly ineffective and potentially detrimental treatment modalities, save for therapeutic phlebotomy [15, 16], including skeletal radiation therapy (1917) [17], acetylphenylhydrazine (1918) [18], potassium arsenite (1933) [19], radiophosphorus (P32) (1940) [20], lead acetate (1942) [21], nitrogen mustard (1950) [22], triethylene melamine (1952) [23], pyrimethamine (1954) [24], busulfan (1958) [25], 6-mercaptopurine (1962) [26], pipobroman (1962) [27], uracil mustard (1964) [28], chlorambucil (1965) [29], and dapsone (1966) [30]