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These findings suggest that intestinal AMPK could play a central role in maintaining intestinal homeostasis, including microbial composition, as a possible upstream mediator of intestinal NAMPT-mediated NAD + biosynthesis

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However, the demonstration by other authors that treatment with exenatide inhibits apoptosis and oxidative stress and activates survival kinases in pig myocardium after an ischemia-reperfusion procedure45 suggests the need for designing additional studies to clarify the beneficial impact of strategies based on GLP-1 in this experimental model