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3 The regulatory effects of DPP-4is on gut microbiota and GLP-1 secretion: integrating the gut microbiota-SCFAs-GLP-1 axis in the antiepileptic hypothesis Of note, DPP-4is have been demonstrated to exert consistent modulatory effects on the gut microbiota in clinical trials and animal studies of various disease models, including type 2 diabetes and fatty liver disease ( In addition to the modulatory effects of DPP-4is on the gut microbiota, they can also increase plasma concentration of their core substrate GLP-1
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