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For comparison: The number needed to treat (NNT) to prevent one major cardiovascular event with semaglutide in the SELECT trial was 67 over 3 years (Lincoff et al., New England Journal of Medicine 2023) The NNT to achieve 10% or more weight loss with tirzepatide in SURMOUNT-1 was 1.4 (Jastreboff et al., New England Journal of Medicine 2022) The benefit-risk calculus strongly favors treatment for most patients
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