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According to the SmPC, the most frequently reported adverse effects of Rybelsus include: Nausea (frequency varies by dose, commonly reported) Diarrhoea Vomiting Abdominal pain Decreased appetite Constipation Dyspepsia (indigestion) These gastrointestinal symptoms are typically most pronounced during treatment initiation and dose escalation, often diminishing over time as the body adjusts to the medication
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