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In the remainder of this review, we refer to endogenous GLP-1 simply as ‘GLP-1,’ whereas exogenous GLP-1 is referred to as ‘GLP-1RAs.’ Preclinical studies have demonstrated that GLP-1R activation can reduce the reinforcing properties of addictive substances, suppress drug-seeking behaviors, and attenuate cue-induced reinstatement of use [7,10,11]