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Mouse islets were incubated in KRBH buffer supplemented with 3 mM glucose for 1 hour followed by stimulation in KRBH buffer supplemented with 11 mM glucose ± 100 nM exendin-4 for 30 minutes

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These preclinical data demonstrated a critical role for GLP-1R in controlling alcohol consumption, but the impact of GLP-1 has been less studied